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KMID : 1123920110250010092
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Korean Journal of Oriental Physiology and Pathology
2011 Volume.25 No. 1 p.92 ~ p.99
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Screening of Antioxidative Effect and Suppressive Effect of LDL Oxidation of Euryale ferox Salisbury
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Kim Yong-Hwan
Lee Min-Ja
Lee Hye-Sook
Kim Jung-Guk
Park Won-Hwan
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Abstract
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Topical natural antioxidants are a useful strategy for the prevention of oxidative stress mediated cardiovascular disease including atherosclerosis. From the viewpoint of this underlying principle, the screening of natural plant extracts with scavenging activity for pro-oxidant reactive species is a primary requirement for the development of new topical antioxidant formulations. Euryale ferox Salisbury (EF) is botanical name and it’s pharmaceutical name is EURYALES SEMEN (ES). The stems and branchs of EF have been used as a traditional herbal medicine for the treatment of dysentery, diarrhea, leucorrhoea, incontinence and paralysis of joint. In this study, the antioxidant activity of extract from EF was studied in vitro methods by measuring the antioxidant activity and free radical scavenging activity by TEAC and DPPH, measuring the scavenging effects on reactive oxygen species (ROS) [superoxide anion, hydroxyl radical] and on reactive nitrogen species (RNS) [nitric oxide and peroxynitrite] as well as measuring the inhibitory effect on Cu²-induced human LDL oxidation. The EF extracts were found to have a potent scavenging activity, as well as an inhibitory effect on LDL oxidation. In conclusion, the EF extracts have antioxidative effects in vitro system, which can be used for developing pharmaceutical drug against oxidative stress and chronic degenerative disease such as atherosclerosis.
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KEYWORD
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Euryale ferox Salisbury (EF), oxidative stress, antioxidative, ROS & RNS, LDL oxidation
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